David M Loeb Selected Research

temsirolimus

1/2018

A phase II study of temsirolimus and liposomal doxorubicin for patients with recurrent and refractory bone and soft tissue sarcomas.

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David M Loeb Research Topics

Disease

36	Neoplasms (Cancer) 02/2024 - 08/2002
12	Sarcoma (Soft Tissue Sarcoma) 01/2020 - 12/2011
11	Ewing Sarcoma (Sarcoma, Ewing) 02/2024 - 11/2010
10	Osteosarcoma (Osteogenic Sarcoma) 01/2020 - 01/2009
7	Neoplasm Metastasis (Metastasis) 10/2020 - 10/2015
5	Hematologic Neoplasms (Hematological Malignancy) 12/2016 - 06/2013
4	Leukemia 12/2016 - 12/2009
3	Residual Neoplasm 01/2021 - 07/2014
3	Chordoma 01/2017 - 10/2011
3	Aplastic Anemia (Anemia, Hypoplastic) 11/2016 - 12/2007
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2023 - 07/2014
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2018 - 08/2002
2	Wilms Tumor (Wilm's Tumor) 10/2018 - 12/2016
2	Pain (Aches) 12/2016 - 06/2013
2	Hypoxia (Hypoxemia) 01/2015 - 12/2011
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 07/2014 - 07/2014
2	Disease Progression 07/2014 - 01/2013
2	Infections 11/2009 - 04/2008
1	Respiratory Insufficiency (Respiratory Failure) 01/2023
1	Pneumonia (Pneumonitis) 01/2023
1	Rhabdoid Tumor (Rhabdoid Tumors) 10/2022
1	Neuroblastoma 08/2021
1	Peripheral Nervous System Diseases (PNS Diseases) 02/2020
1	Peripheral Nervous System Neoplasms 01/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020
1	Rhabdomyosarcoma 02/2018
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 01/2018
1	Alveolar Rhabdomyosarcoma 10/2017
1	Circulating Neoplastic Cells 10/2017
1	Hemorrhage 10/2017
1	Proteinuria 10/2017
1	Embolism (Embolus) 10/2017
1	Hypertension (High Blood Pressure) 10/2017
1	Thrombosis (Thrombus) 10/2017
1	Wounds and Injuries (Trauma) 10/2017

Drug/Important Bio-Agent (IBA)

6	Proteins (Proteins, Gene)FDA Link 02/2024 - 06/2006
6	Cyclophosphamide (Cytoxan)FDA LinkGeneric 12/2017 - 05/2003
4	Transcription Factors (Transcription Factor)IBA 01/2015 - 12/2009
4	Small Interfering RNA (siRNA)IBA 01/2015 - 10/2011
3	Cisplatin (Platino)FDA LinkGeneric 01/2023 - 10/2017
3	EWS-FLI fusion proteinIBA 01/2021 - 11/2010
3	Dasatinib (BMS 354825)FDA Link 01/2018 - 03/2016
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2017 - 12/2011
3	samarium Sm-153 lexidronam (Quadramet)FDA Link 06/2013 - 06/2009
3	phosphonic acidIBA 06/2013 - 06/2009
3	Samarium-153IBA 07/2011 - 06/2009
2	RNA Helicases (RNA Helicase)IBA 02/2024 - 06/2023
2	Chimeric Antigen ReceptorsIBA 01/2023 - 01/2015
2	Bortezomib (Velcade)FDA Link 08/2021 - 06/2013
2	RNA (Ribonucleic Acid)IBA 01/2021 - 10/2017
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 10/2016
2	Antineoplastic Agents (Antineoplastics)IBA 02/2020 - 03/2011
2	PlatinumIBA 02/2020 - 04/2005
2	Docetaxel (Taxotere)FDA Link 01/2020 - 06/2013
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2018 - 01/2015
2	Monoclonal AntibodiesIBA 10/2017 - 04/2016
2	Bevacizumab (Avastin)FDA Link 10/2017 - 05/2014
2	WT1 ProteinsIBA 12/2016 - 12/2011
2	AntigensIBA 12/2016 - 01/2015
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2023
1	tisagenlecleucelIBA 01/2023
1	Etanercept (Enbrel)FDA Link 01/2023
1	pembrolizumabIBA 10/2022
1	Carrier Proteins (Binding Protein)IBA 08/2021
1	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2021
1	Proteasome InhibitorsIBA 08/2021
1	selinexorIBA 08/2021
1	Nucleic AcidsIBA 01/2021
1	Cell-Free Nucleic AcidsIBA 01/2021
1	plerixafor FDA Link 01/2021
1	S-Phase Kinase-Associated Proteins (Skp1 Protein)IBA 10/2020
1	Carboplatin (JM8)FDA LinkGeneric 02/2020
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 02/2020
1	taxaneIBA 01/2020
1	saracatinibIBA 01/2020
1	Cysteine (L-Cysteine)FDA Link 01/2020
1	Gemcitabine FDA Link 01/2020
1	130-nm albumin-bound paclitaxelIBA 01/2020
1	liposomal doxorubicin (Doxil)FDA Link 01/2018
1	IronIBA 01/2018
1	temsirolimus FDA Link 01/2018
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2018
1	Sunitinib (Sutent)FDA Link 01/2018
1	Imatinib Mesylate (Gleevec)FDA Link 01/2018
1	SulfurIBA 01/2018
1	regorafenibIBA 01/2018
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/2018
1	LGK974IBA 10/2017
1	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2017

Therapy/Procedure

25	Therapeutics 01/2023 - 08/2002
18	Drug Therapy (Chemotherapy) 10/2020 - 08/2002
6	Transplantation 12/2016 - 01/2009
4	Hematopoietic Stem Cell Transplantation 10/2018 - 03/2011
4	Surgical Amputation (Amputations) 10/2017 - 01/2009
2	Cell Transplantation 01/2023 - 07/2014
2	Aftercare (After-Treatment) 01/2023 - 05/2003
2	Bone Marrow Transplantation (Transplantation, Bone Marrow) 12/2017 - 01/2016
2	Radiotherapy 06/2013 - 06/2009
2	Immunotherapy 01/2009 - 05/2007
1	Bioreactors (Bioreactor) 11/2018